At the second annual Pathways to Genomics and Proteomics Day, twenty-five local middle and high school students from the Yale Pathways to Science program spent the day on campus learning about “omics” science and the cutting-edge research driving future discoveries in personalized medicine. To kick-off the event, Sarah Slavoff, of the Chemical Biology Institute, first introduced students to the human genome and later Yale graduate students and post-docs from Cell Biology, Chemistry, Genetics, Molecular, Cellular and Developmental Biology, and Neuroscience departments led a variety of hands-on activities and demonstrations. Among the activities, students were able to make green fluorescent protein stickers, tour the Yale Center for Genome Analysis, discuss ‘bad science’ in movies, learn about mass spectrometry, and create their own DNA necklaces.